Podophyllotoxin (PPT) exhibited significant activity against P-glycoprotein mediated
multidrug resistant (MDR) tumor cell lines; however, due to its poor solubility and high …

Purpose: Here we report on the role of mitochondria, death receptors (DRs), and caspases
in exerting the cytotoxic effect of clinically relevant concentrations of paclitaxel in the non …

Cancer theranosis is an emerging field of personalized medicine which enables individual
anti-cancer treatment by monitoring the therapeutic responses of cancer patients. Based on …

Background and purpose: We report the development of a very efficient cell‐based high
throughput screening (HTS) method, which utilizes a novel bio‐sensor that selectively …

Objective The aim of the study was to develop stable Paclitaxel nanocrystals (PTX/NCs) for
enhanced oral delivery of Paclitaxel (PTX) by circumventing its difficult solubilization …

Background/Aim: Fluoxetine, an antidepressant, has cytotoxic effects on several cancer cell
lines, while paclitaxel is an antineoplastic agent for various cancers. The aim of this study …

Contrary to oversimplified preclinical drug screens that derive treatment responses of cancer
cells grown on plastic cell culturing surfaces, the actual in vivo scenario for cancer cell …

β-elemene has recently raised interest in PR China as a novel antitumor plant drug isolated
from the Chinese medicinal herb Zedoary. To explore potentially useful combinations of β …

Aim: To develop selenium nanoparticles (SeNPs)-based delivery systems for paclitaxel
(PTX) and assess their antiproliferative efficacy against cancer cells in vitro with potential …

Covalently bonded Eudragit S-100 (EU) and chitosan (CS) based colon-specific
nanoparticles (CSE NPs) were fabricated as drug carriers for treating colorectal cancers …