This rapid report focuses on the pharmacodynamic mechanism of the carboplatin/paclitaxel
combination and correlates it with its cytotoxicity. Consistent with the synergistic to additive …

Despite decades of effort, pancreatic adenocarcinoma (PDAC) remains an intractable
clinical challenge. An insufficient understanding of mechanisms underlying tumor cell …

Nanomaterials have drawn significant attention for their biomedical and pharmaceutical
applications. In the present study, manganese tetra oxide (Mn 3 O 4) nanoparticles were …

We have developed a generic approach to determine enzyme activities in vitro and monitor
their functional status in vivo. Specifically, a method to generate donor (CbOH)− acceptor …

Background We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel,
novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53 …

Apoptosis-related proteins play an important role in lymphoma cell death during
chemotherapy. In our study, we investigated the prognostic significance of CD95, BCL2, and …

In this study antiproliferation, cell cycle arrest and apoptosis induced by daphnoretin in
human osteosarcoma (HOS) cells were investigated. Antiproliferative activity was measured …

Background Bladder cancer is the second common malignancy of genitourinary tract, and
transitional cell carcinomas (TCCs) account for 90% of all bladder cancers. Due to acquired …

Background: The aim of the study was to contribute to our understanding of the mechanisms
responsible for the resistance of breast cancer cells to taxanes. Materials and Methods: Cell …

Purpose Paclitaxel is an important agent in the pharmacological treatment of metastatic
breast cancer. Despite its efficacy in selected patients, the majority of patients have a …