In recent studies, epothilone B was shown to have a cytotoxic and radiosensitizing effect on
cells. The aim of our investigation was to explain this impact by examining the mode of …

Synthetic small molecule tubulin inhibitors have many advantages as novel anti-cancer
agents compared to the current tubulin inhibitors generated from natural products. Our …

Pancreatic cancer (PC) is a highly malignant cancer with poor prognosis. Although
gemcitabine (GEM; 2′, 2′-difluoro-deoxycytidine) has been used as the first-line …

Breast cancer is the leading cause of cancer death among females worldwide (Jemal et al.,
2011). There were approximately 1.7 million and 500,000 of new cases and deaths due to …

RESUMO O carcinoma espinocelular (CEC) oral representa mais de 90% das neoplasias
malignas que acometem a cavidade oral e tem como principal determinante de prognóstico …

Colorectal carcinoma is mostly common and fatal, even holding a third rank in males and a
second in females in the causes of cancer-related death worldwide 1, 2), due to current …

The rapidly advancing fields of pharmaceutical and clinical research call for systematic,
molecular-level characterization of complex biological systems and diseases. To this end …

Objective Epigenetic therapies have already been introduced into clinical cancer
management. The main objective of this study is to explore the potential of modulating …

High expression of TAOK3 has been observed in several cancers, but very little about
TAOK3-involved mechanisms has been reported. In this study, we investigated the role of …

Despite decades of effort, pancreatic adenocarcinoma (PDAC) remains an intractable
clinical challenge. An insufficient understanding of mechanisms underlying tumor cell …