The pharmacological characteristics of phytochemicals have prompted a lot of interest in
their application in disease management. Due to the high incidence of cancer related …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells
found in complex tissues. This dynamic process helps organize the formation of the body …

Background & Aims Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol
biosynthesis, is suggested as a proto-oncogene. Paradoxically, SQLE is degraded by …

The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the
absence of cellular stress, the p53 protein is maintained at low steady-state levels and …

Abstract vitexin, an apigenin-8-C-glucoside, is widely present in numerous edible and
medicinal plants. vitexin possesses a variety of bioactive properties, including antioxidation …

Abstract Background/Aim Probiotics have been suggested as prophylactic measure in colon
carcinogenesis. This study aimed at determining the potential prophylactic activity of …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Cancer development depends on the aberrant activation of signal transduction pathways
that control cell growth and survival and play important roles in normal embryonic …

Although glycogen synthase kinase‐3 beta (GSK‐3β) was originally named for its ability to
phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional …