Rationale: We recently reported that ramipril more than doubled maximum walking times in
patients with peripheral artery disease with intermittent claudication. Objective: Our aim was …

Most physiological processes are subjected to molecular regulation by growth factors, which
are secreted proteins that activate chemical signal transduction pathways through binding of …

Microvascular remodeling is a complex process that includes many cell types and molecular
signals. Despite a continued growth in the understanding of signaling pathways involved in …

The Physiome projects comprise a loosely knit worldwide effort to define the Physiome
through databases and theoretical models, with the goal of better understanding the …

Development of clinical-sized three-dimensional (3D) tissue engineering constructs requires
an extensive blood vessel network to provide the cells with necessary nutrients and other …

A brief introduction to cancer biology and treatment is presented with a focus on current
clinical advances in the delivery of chemotherapy and antiangiogenic therapies …

Angiogenesis and vasculogenesis as a critical and multisca various models have been
developed to understand how end These models can be classified in three major groups …

Tyrosine kinase receptor (RTK) ligation and dimerization is a key mechanism for translating
external cell stimuli into internal signaling events. This process is critical to several key cell …

Introduction: More than 20 million people in Europe suffer from peripheral arterial disease
and nearly 3% develop critical limb ischemia (CLI). Without any medical treatment, CLI has …

Angiogenesis research has already led to therapies for cancer, anemia, macular
degeneration, and ischemia. In the coming decade, half a billion people worldwide are …