Epidermolysis bullosa (EB) is a group of rare congenital diseases caused by mutations in
structural proteins of the dermal/epidermal junction that are characterized by extreme …

Dystrophic epidermolysis bullosa is a rare genetic skin disorder caused by COL7A1
sequence variations that result in type VII collagen deficits and cutaneous and …

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in
white populations, accounting for 20% of all cutaneous malignancies. Overall, cSCC mostly …

Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is
known about how it predisposes the tissue microenvironment preceding tumor formation …

Simple Summary Cutaneous squamous cell carcinomas (SCCs) are the most common
tumors in patients suffering from the genetic disorder epidermolysis bullosa (EB). These …

Background Cutaneous squamous cell carcinoma (SCC) is the leading cause of death in
patients with recessive dystrophic epidermolysis bullosa (RDEB). However, the survival time …

Recessive dystrophic epidermolysis bullosa is a debilitating blistering skin disorder caused
by loss-of-function mutations in COL7A1, which encodes type VII collagen, the main …

Background Itch is common and distressing in epidermolysis bullosa (EB) but has not
previously been studied in depth in different recessive dystrophic EB (RDEB) subtypes …

Cutaneous squamous cell carcinoma (cSCC) is a major complication of recessive dystrophic
epidermolysis bullosa (RDEB) that has high morbidity and mortality rates and unmet …

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin disease
characterized by defects in type VII collagen leading to a range of fibrotic pathologies …