A brief review of the biological potential of indole derivatives
S Kumar, Ritika - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …
clinical and biological applications. Indole scaffold has been found in many of the important …
A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Clean grinding technique: A facile synthesis and in silico antiviral activity of hydrazones, pyrazoles, and pyrazines bearing thiazole moiety against SARS-CoV-2 main …
S Abu-Melha, MM Edrees, SM Riyadh, MR Abdelaziz… - Molecules, 2020 - mdpi.com
A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop
grinding of thiazole carbohydrazide 2 with various carbonyl compounds. Also, dehydrative …
grinding of thiazole carbohydrazide 2 with various carbonyl compounds. Also, dehydrative …
Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co (II), Ni (II), Cu (II), Zn (II), and Ru (III) …
Metal-based drugs have gained significant importance in medicine in recent years. In this
research, a series of new Co (II), Ni (II), Cu (II), Zn (II), and Ru (III) complexes of a Schiff base …
research, a series of new Co (II), Ni (II), Cu (II), Zn (II), and Ru (III) complexes of a Schiff base …
Chemistry of 2-vinylindoles: Synthesis and applications
YAAM Elshaier, MTM Nemr, MS Refaey… - New Journal of …, 2022 - pubs.rsc.org
As a class of compounds, 2-vinylindoles have demonstrated a wide range of biological
properties. These synthons have been studied extensively so far in the literature, a new …
properties. These synthons have been studied extensively so far in the literature, a new …
New bis hydrazone: synthesis, X-ray crystal structure, DFT computations, conformational study and in silico study of the inhibition activity of SARS-CoV-2
A Tabbiche, A Bouchama, N Chafai, F Zaidi… - Journal of Molecular …, 2022 - Elsevier
The aim of this work was to synthesize new bis hydrazone derived from benzil in good yield,
namely:(1Z, 2Z)-1, 2-bis (3-Chlorophenyl Hydrazino) Benzil, encoded by 3-Cl BHB. The …
namely:(1Z, 2Z)-1, 2-bis (3-Chlorophenyl Hydrazino) Benzil, encoded by 3-Cl BHB. The …
Schiff base derivatives of 4-aminoantipyrine as promising molecules: synthesis, structural characterization, and biological activities
In this study, some Schiff bases derived from 4-aminoantipyrine (4-AAP)(VI–X) were
synthesized, characterized by elemental analysis (C, H, N) and three spectral techniques …
synthesized, characterized by elemental analysis (C, H, N) and three spectral techniques …
Anticholinesterase activities of novel indole-based hydrazide-hydrazone derivatives: design, synthesis, biological evaluation, molecular docking study and in silico …
ED Coşar, ED Dincel, S Demiray, E Sucularlı… - Journal of Molecular …, 2022 - Elsevier
A series of novel indole-based hydrazide-hydrazone derivatives were synthesized and
evaluated for their AChE and BuChE inhibitory activities. The structural elucidations of the …
evaluated for their AChE and BuChE inhibitory activities. The structural elucidations of the …
Synthesis of novel tritopic hydrazone ligands: spectroscopy, biological activity, DFT, and molecular docking studies
Polytopic organic ligands with hydrazone moiety are at the forefront of new drug research
among many others due to their unique and versatile functionality and ease of strategic …
among many others due to their unique and versatile functionality and ease of strategic …
Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties
Nine novel hydrazone derivatives (4a–i) incorporating pyridine and isatin moieties were
synthesized through one‐pot, four‐component heterocyclic condensation reactions. The …
synthesized through one‐pot, four‐component heterocyclic condensation reactions. The …