Purpose The increase of IOP in POAG is due an increased resistance of aqueous outflow
through the trabecular meshwork (TM). Methods The exact mechanisms leading to the …

Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage and
reducing IOP improves prognosis. Nevertheless, there is little doubt that other risk factors …

Oxidative stress contributes to dysfunction of glial cells in the optic nerve head (ONH).
However, the biological basis of the precise functional role of mitochondria in this …

purpose. There is growing evidence that oxidative stress contributes to the progression of
primary open-angle glaucoma (POAG), a leading cause of irreversible blindness worldwide …

This review describes the clinical and basic research that led to the description of Flammer
syndrome. It is narrated from a personal perspective. This research was initiated by the …

Open-angle glaucoma (OAG) is the commonest cause of irreversible blindness worldwide.
Apart from an increased intraocular pressure (IOP), oxidative stress and an impaired ocular …

Glaucoma is a major ocular neurodegenerative disease characterized by progressive retinal
ganglion cells degeneration and sight loss. Current treatment options have been limited to …

Background Caffeine is widely consumed, and its effect on intraocular pressure (IOP) has
been reported in conflicting data. The aim of this meta-analysis was to quantitatively …

Rhodopsin (Rho) is a visual G protein–coupled receptor expressed in the rod
photoreceptors of the eye, where it mediates transmission of a light signal into a cell and …

Neuroglobin (NGB), a newly discovered member of the globin superfamily, may regulate
neuronal survival under hypoxia or oxidative stress. Although NGB is greatly expressed in …