The glymphatic system: a novel component of fundamental neurobiology
LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
Selective neuronal vulnerability in Parkinson disease
DJ Surmeier, JA Obeso, GM Halliday - Nature Reviews Neuroscience, 2017 - nature.com
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …
An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings
The brain is constituted of multiple networks of functionally correlated brain areas, out of
which the default-mode network (DMN) is the largest. Most existing research into the DMN …
which the default-mode network (DMN) is the largest. Most existing research into the DMN …
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …
compacta and subsequent reduction of dopamine levels in striatum are associated with …
The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …
implications. Clinical and experimental studies on aging have uncovered numerous …
The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease
L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …
increased risk of obese people to develop brain diseases such as cognitive and mood …
The mechanisms of action of curcumin in Alzheimer's disease
M Tang, C Taghibiglou - Journal of Alzheimer's disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As the prevalence
of AD rises in the 21st century, there is an urgent need for the development of effective …
of AD rises in the 21st century, there is an urgent need for the development of effective …
The immunopathogenesis of Alzheimer's disease is related to the composition of gut microbiota
F Leblhuber, D Ehrlich, K Steiner, S Geisler, D Fuchs… - Nutrients, 2021 - mdpi.com
The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …
mapped the activity and functional connectivity of cholinergic neurons have shown that the …
[HTML][HTML] Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …