Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
[HTML][HTML] Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
Nutrient scavenging in cancer
BT Finicle, V Jayashankar, AL Edinger - Nature Reviews Cancer, 2018 - nature.com
While cancer cell proliferation depends on access to extracellular nutrients, inadequate
tumour perfusion means that glucose, amino acids and lipids are often in short supply. To …
tumour perfusion means that glucose, amino acids and lipids are often in short supply. To …
Cancer stem cells and immunosuppressive microenvironment in glioma
Glioma is one of the most common malignant tumors of the central nervous system and is
characterized by extensive infiltrative growth, neovascularization, and resistance to various …
characterized by extensive infiltrative growth, neovascularization, and resistance to various …
Concise reviews: cancer stem cell targeted therapies: toward clinical success
A Desai, Y Yan, SL Gerson - Stem cells translational medicine, 2019 - academic.oup.com
Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem
cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate …
cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate …
Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
Role of hypoxia inducible factor-1 in cancer stem cells
Q Zhang, Z Han, Y Zhu, J Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
Modulation of the tumor microenvironment (TME) by melatonin
Q Mu, M Najafi - European journal of pharmacology, 2021 - Elsevier
The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …
The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions
Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a
population of self-renewing, therapeutically resistant cancer stem cells (CSCs) …
population of self-renewing, therapeutically resistant cancer stem cells (CSCs) …
Targeting phosphatases and kinases: How to checkmate cancer
A Turdo, C D'Accardo, A Glaviano, G Porcelli… - Frontiers in cell and …, 2021 - frontiersin.org
Metastatic disease represents the major cause of death in oncologic patients worldwide.
Accumulating evidence have highlighted the relevance of a small population of cancer cells …
Accumulating evidence have highlighted the relevance of a small population of cancer cells …