Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

While cancer cell proliferation depends on access to extracellular nutrients, inadequate
tumour perfusion means that glucose, amino acids and lipids are often in short supply. To …

Glioma is one of the most common malignant tumors of the central nervous system and is
characterized by extensive infiltrative growth, neovascularization, and resistance to various …

Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem
cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate …

Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect
cancer cell survival. Although CD8+ T lymphocytes and natural killer (NK) cells suppress …

Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a
population of self-renewing, therapeutically resistant cancer stem cells (CSCs) …

Metastatic disease represents the major cause of death in oncologic patients worldwide.
Accumulating evidence have highlighted the relevance of a small population of cancer cells …