Injured peripheral nerves but not central nerves have the capacity to regenerate and
reinnervate their target organs. After the two most severe peripheral nerve injuries of six …

Injured peripheral nerves regenerate their lost axons but functional recovery in humans is
frequently disappointing. This is so particularly when injuries require regeneration over long …

Biomimetic scaffolds supporting tissue regeneration are complex materials with
multifunctional characteristics. The unique biocompatibility and biodegradability of …

Enhancing the regeneration of axons is often considered to be a therapeutic target for
improving functional recovery after peripheral nerve injury. In this review, the evidence for …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

The postsurgical period during which neurons remain without target connections (chronic
axotomy) and distal nerve stumps and target muscles are denervated (chronic denervation) …

Damage to the central nervous system (CNS) leads to cellular changes not only in the
affected neurons but also in adjacent glial cells and endothelia, and frequently, to a …

Peripheral nerves are complex organs that can be found throughout the body reaching
almost all tissues and organs to provide motor and/or sensory innervation. A parenchyma …

Peripheral nerve injury is common especially among young individuals. Although injured
neurons have the ability to regenerate, the rate is slow and functional outcomes are often …

Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …