Nonsteroidal anti‐inflammatory drugs (NSAIDs) are the most commonly used drugs
worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

The association between hyperuricemia and cardiovascular disease (CVD) has been
reported and studied in the past two decades. Xanthine oxidase (XO) induced uric acid (UA) …

Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase
(SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) …

Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and
mitochondrial dysfunction. Because mitochondria are both a source and target of ROS, we …

Re-canalization of cerebral vessels in ischemic stroke is pivotal to rescue dysfunctional
brain areas that are exposed to moderate hypoxia within the penumbra from irreversible cell …

Background Longitudinal strain (LS) is a sensitive marker of systolic function. Recent
findings suggest that both myocardial contractility and loading conditions determine LS. The …

Significant advances in our understanding of the ability of nitric oxide synthases (NOS) to
modulate cardiac function have provided key insights into the role NOS play in the …

The heart grows in response to changes in hemodynamic loading during normal
development and in response to valve disease, hypertension, and other pathologies. In …

Monitoring the bioenergetics of leucocytes is now emerging as an important approach in
translational research to detect mitochondrial dysfunction in blood or other patient samples …