Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem
cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks …

Lipids, the basic components of the cell membrane, execute fundamental roles in almost all
the cell activities including cell-cell recognition, signalling transduction and energy supplies …

Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently
resistant cancer cells or by the adaptive plasticity of initially sensitive cancer cells. We …

Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …

Cellular heterogeneity poses an immense therapeutic challenge in cancer due to a constant
change in tumor cell characteristics, endowing cancer cells with the ability to dynamically …

Chemotherapy currently remains the standard treatment for triple-negative breast cancer
(TNBC). However, TNBC frequently develop chemoresistance, which is responsible for …

Solid tumors comprise of maturated cancer cells and self-renewing cancer stem-like cells
(CSCs), which are associated with various other nontumorigenic cell populations in the …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that disproportionally
accounts for the majority of breast cancer-related deaths due to the lack of specific targets for …

Ovarian cancer is the most lethal neoplasm of the female genital organs. Despite
indisputable progress in the treatment of ovarian cancer, the problems of chemo-resistance …