The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

P Nombela, B Miguel-López, S Blanco - Molecular cancer, 2021 - Springer
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Biological roles of RNA m5C modification and its implications in Cancer immunotherapy

H Song, J Zhang, B Liu, J Xu, B Cai, H Yang… - Biomarker …, 2022 - Springer
Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Y Hu, C Chen, X Tong, S Chen, X Hu, B Pan… - Cell death & …, 2021 - nature.com
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …

5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

[HTML][HTML] The role of RNA m5C modification in cancer metastasis

Q Zhang, F Liu, W Chen, H Miao, H Liang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Epigenetic modification plays a crucial regulatory role in the biological processes of
eukaryotic cells. The recent characterization of DNA and RNA methylation is still ongoing …

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation

M Yang, R Wei, S Zhang, S Hu, X Liang, Z Yang… - Cell death & …, 2023 - nature.com
methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase
NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional …

m5C RNA methylation regulators predict prognosis and regulate the immune microenvironment in lung squamous cell carcinoma

J Pan, Z Huang, Y Xu - Frontiers in oncology, 2021 - frontiersin.org
RNA methylation is a novel epigenetic modification that can be used to evaluate tumor
prognosis. However, the underlying mechanisms are unclear. This study aimed to …

Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance

G Guo, K Pan, S Fang, L Ye, X Tong, Z Wang… - … Therapy-Nucleic Acids, 2021 - cell.com
5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …

[HTML][HTML] Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma

M Xue, Q Shi, L Zheng, Q Li, L Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Background: Head and neck squamous cell carcinoma (HNSCC) is the fifth most common
malignancy in the world. The 5-methylcytosine (m5C) plays vital roles in pathological …