[HTML][HTML] Practical strategies for a safe and effective delivery of aerosolized medications to patients with COVID-19

A Ari - Respiratory Medicine, 2020 - Elsevier
The COVID-19, the disease caused by a novel coronavirus and named severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe. It …

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

[HTML][HTML] Oral inhalation for delivery of proteins and peptides to the lungs

E Fröhlich, S Salar-Behzadi - European Journal of Pharmaceutics and …, 2021 - Elsevier
Oral inhalation is the preferred route for delivery of small molecules to the lungs, because
high tissue levels can be achieved shortly after application. Biologics are mainly …

Inhalation therapy devices for the treatment of obstructive lung diseases: the history of inhalers towards the ideal inhaler

C Sorino, S Negri, A Spanevello, D Visca… - European Journal of …, 2020 - Elsevier
Inhalation therapy allows conveying drugs directly into the airways. The devices used to
administer inhaled drugs play a crucial role in the management of obstructive lung diseases …

Nanotechnology as a tool to overcome macromolecules delivery issues

LL Tundisi, JA Ataide, JSR Costa… - Colloids and Surfaces B …, 2023 - Elsevier
Nanocarriers can deliver drugs to specific organs or cells, potentially bridging the gap
between a drug's function and its interaction with biological systems such as human …

Mesh nebulizers have become the first choice for new nebulized pharmaceutical drug developments

JN Pritchard, RHM Hatley, J Denyer… - Therapeutic Delivery, 2018 - Taylor & Francis
In the 24 years since first being marketed, the mesh nebulizer has been developed by five
main manufacturers into a viable solution for the delivery of high-value nebulized drugs …

Lung microbiota: its relationship to respiratory system diseases and approaches for lung-targeted probiotic bacteria delivery

N Yuksel, B Gelmez, A Yildiz-Pekoz - Molecular Pharmaceutics, 2023 - ACS Publications
Microorganisms that make up the local microbiota (such as Lactobacillus sp. and
Bifidobacterium sp.) play a crucial role in the modulation of diseases and health states by …

Antivirals and the potential benefits of orally inhaled drug administration in COVID-19 treatment

G Sahin, O Akbal-Dagistan, M Culha, A Erturk… - Journal of …, 2022 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) pandemic has been on the agenda of
humanity for more than 2 years. In the meantime, the pandemic has caused economic …

Aerosol pulmonary immune engineering

ER Sudduth, M Trautmann-Rodriguez, N Gill… - Advanced Drug Delivery …, 2023 - Elsevier
Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …

Nebulized therapies in COPD: past, present, and the future

IZ Barjaktarevic, AP Milstone - International journal of chronic …, 2020 - Taylor & Francis
Current guidelines recommend inhalation therapy as the preferred route of drug
administration for treating patients with chronic obstructive pulmonary disease (COPD) …