Cancer-induced bone pain is a major clinical problem. A rat model based on intra-tibial
injection of MRMT-1 mammary tumour cells was used to mimic progressive cancer-induced …

ABSTRACT Objective. To validate the Canine Brief Pain Inventory (CBPI), which is based on
the human Brief Pain Inventory (BPI), in a canine model of spontaneous bone cancer …

Current therapies for the treatment of chronic pain provide inadequate relief for millions of
suffering patients, demonstrating the need for better therapies that will treat pain effectively …

Inflammation and cancer, two therapeutic areas historically addressed by separate drug
discovery efforts, are now coupled in treatment approaches by a growing understanding of …

Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic
agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium …

A number of previous reviews have very eloquently summarized pain models and endpoints
in animals. Many of these reviews also discuss how animal models have enhanced our …

Background There is current interest in understanding the molecular mechanisms of tumor-
induced bone pain. Accumulated evidence shows that endogenous formaldehyde …

Pain is the most common presenting symptom in patients with bone cancer and bone cancer
pain can be both debilitating and difficult to control fully. To begin to understand the …

Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous
pain accompanied by hyperalgesia that typically arises from bone metastases or primary …

Background Cancer-induced bone pain is a major clinical problem for which current
treatments lack full efficacy. Gabapentin is licensed for use in neuropathic pain yet is also …