The understanding and recognition of pain in laboratory rats and mice has advanced
considerably in recent times. However, there is evidence that despite these advances …

It has been reported that remarkable and sustained activation of astrocytes and/or microglia
occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory …

Pain caused by the tumor or aromatase inhibitors (AIs) is a disabling symptom in breast
cancer survivors. Their mechanisms are unclear, but pro-algesic and inflammatory …

Bone cancer induced dynamic changes of A-type K+ channels in dorsal root ganglion
neurons. Diclofenac antagonized bone cancer pain by upregulating peripheral A-type K+ …

Patients with bone cancer pain (BCP) are more prone to aversion. which not only causes
mental distress but also aggravates BCP. However, the mechanism of BCP-related aversion …

Animal models of pain consist of modeling a pain-like state and measuring the consequent
behavior. The first animal models of neuropathic pain (NP) were developed in rodents with a …

Mechanisms of inflammatory and neuropathic pains have been elucidated and translated to
patient care by the use of animal models of these pain states. Cancer pain has lagged …

Most preclinical pain models rely on short-duration stimulus-evoked hind paw
measurements even though chronic pain is usually a day and night experience. Pain is a …

N-docosahexaenoylethanolamine (DHEA), or synaptamide, is an endogenous metabolite of
docosahexaenoic acid (DHA) that exhibits synaptogenic and neurogenic effects. In our …

Background Activation of adenosine monophosphate–activated kinase (AMPK) has been
associated with the inhibition of inflammatory nociception and the attenuation of morphine …