Functional and anatomical relationships among primary afferent fibers, blood vessels, and
cancers are poorly understood. However, recent evidence suggests that physical and …

Bone metastases impair general health status, quality of life and survival of patients.
Electrochemotherapy (ECT), which combines electroporation (EP) and the administration of …

Experimental animal models of bone cancer pain have emerged and findings have provided
a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key …

Upregulation of P2X3 receptor (P2X3R) has been strongly implicated in nociceptive
signaling including bone cancer pain (BCP). The present study, using rat bone cancer …

Objective Our previous study showed that tumor tissue-derived formaldehyde at low
concentrations plays an important role in bone cancer pain through activating transient …

Although skeletal pain can have a marked impact on a patient's functional status and quality
of life, relatively little is known about the specific populations of peripheral nerve fibers that …

Pain is a common and debilitating complication for cancer patients significantly
compromising their quality of life. Cancer-induced bone pain involves a complex interplay of …

BACKGROUND: Cannabinoids bind to cannabinoid receptors type 1 and 2 and produce
analgesia in several pain models, but central side effects from cannabinoid 1 receptors limit …

Pain is an unpleasant sensory and emotional experience associated with various diseases.
Extensive research has been conducted to find appropriate methods of relieving pain and …

Background Peripheral nerve injury is a worldwide clinical problem, and the preferred
surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to …