DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Recent advances have uncovered a previously unknown function of vitamin C in epigenetic
regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH …

Astrocytes express a variety of G protein–coupled receptors and might influence cognitive
functions, such as learning and memory. However, the roles of astrocytic Gs-coupled …

Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …

Alzheimer's disease (AD) is a type of incurable neurodegenerative disease that is
characterized by the accumulation of amyloid-β (Aβ; plaques) and tau hyperphosphorylation …

Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease …