Since the beginning of human history, the demand for effective healthcare systems for
diagnosis and treatment of health problems has grown steadily. However, traditional …

Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial
number of patients facing drug-resistant epilepsy. This comprehensive review explores …

This review offers the basics of lentiviral vector technologies, their advantages and pitfalls,
and an overview of their use in the field of ophthalmology. First, the description of the global …

Precision medicine is an old concept, but it is not widely applied across human health
conditions as yet. Numerous attempts have been made to apply precision medicine in …

Nucleic acid delivery with cationic polymers is a promising alternative to expensive viral-
based methods; however, it often suffers from a lower performance. Herein, we present a …

Objective: Epilepsy is a complex disease spanning across multiple scales, from ion
channels in neurons to neuronal circuits across the entire brain. Over the past decades …

Osteoarthritis (OA) is a chronic joint disease characterized by cartilage imbalance and
disruption of cartilage extracellular matrix secretion. Identifying key genes that regulate …

The recent success of first central nervous system gene therapies has reinvigorated the
growing community of gene therapy researchers and strengthened the field's market …

In vitro preparations (defined here as cultured cells, brain slices, and isolated whole brains)
offer a variety of approaches to modeling various aspects of seizures and epilepsy. Such …

Lafora disease is a rare genetic disorder characterized by a disruption in glycogen
metabolism. It manifests as progressive myoclonus epilepsy and cognitive decline during …