Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Z Sun, D Zhu, H Zhao, J Liu, P He, X Luan, H Hu… - Journal of …, 2023 - Springer
Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to
their unique chemical, physical, and biological properties and functions. In this …

Hydrogel and nanomedicine‐based multimodal therapeutic strategies for spinal cord injury

P Yin, W Liang, B Han, Y Yang, D Sun, X Qu… - Small …, 2024 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and
biological factors, manifesting as a loss of motor and sensory functions. Inhibition of injury …

The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?

F Corsi, G Deidda Tarquini, M Urbani, I Bejarano… - Nanomaterials, 2023 - mdpi.com
Cerium oxide nanoparticles (CNPs) are biocompatible nanozymes exerting multifunctional
biomimetic activities, including superoxide dismutase (SOD), catalase, glutathione …

Hierarchically patterned protein scaffolds with nano-fibrillar and micro-lamellar structures modulate neural stem cell homing and promote neuronal differentiation

J Hu, C Li, Z Yang, Q Wu, J Wang, Z Xu, Y Chen… - Biomaterials …, 2023 - pubs.rsc.org
Biophysical factors are essential in cell survival and behaviors, but constructing a suitable
3D microenvironment for the recruitment of stem cells and exerting their physiological …

Application of injectable hydrogels as delivery Systems in Spinal Cord Injury

R Ji, Z Hao, H Wang, X Li, L Duan, F Guan, S Ma - Gels, 2023 - mdpi.com
Spinal cord injury (SCI) is a severe neurological injury caused by traffic accidents, trauma, or
falls, which leads to significant loss of sensory, motor, and autonomous functions and …

[HTML][HTML] Multistructured hydrogel promotes nerve regeneration

N Zhu, Y Zhuang, W Sun, J Wang, F Wang… - Materials Today …, 2024 - Elsevier
Hydrogels have emerged as promising biomaterials for nerve regeneration due to their
adjustable properties, structural resemblance to the extracellular matrix, and ability to …

[HTML][HTML] Metformin induces M2 polarization via AMPK/PGC-1α/PPAR-γ pathway to improve peripheral nerve regeneration

Z Zhou, G Luo, C Li, P Zhang, W Chen, X Li… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Objectives: Investigating the effect of metformin on peripheral nerve regeneration and the
molecular mechanism. Methods: In this study, a rat model of sciatic nerve injury and an …

The Promising Role of a Zebrafish Model Employed in Neural Regeneration Following a Spinal Cord Injury

CW Zeng, HJ Tsai - International Journal of Molecular Sciences, 2023 - mdpi.com
Spinal cord injury (SCI) is a devastating event that results in a wide range of physical
impairments and disabilities. Despite the advances in our understanding of the biological …

[HTML][HTML] IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway

Y Sun, X Song, Z Geng, Y Xu, L Xiao, Y Chen… - International …, 2024 - Elsevier
Objective Excess reactive oxygen species (ROS) generated by oxidative stress is a crucial
factor affecting neuronal dysfunction after spinal cord injury (SCI). IL-11 has been reported to …

[HTML][HTML] Association between Neural Stem/Progenitor Cells and Biomaterials in Spinal Cord Injury Therapies: A Systematic Review and Network Meta-Analysis

J Jeon, SH Park, J Choi, SM Han, HW Kim, SR Shim… - Acta Biomaterialia, 2024 - Elsevier
Spinal cord injury (SCI) is associated with substantial healthcare challenges, frequently
resulting in enduring sensory and motor deficits alongside various chronic complications …