Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Thrombus formation is increased under conditions of hypoxia in animal models of
thrombosis and in human populations, but current therapies for thrombosis do not directly …

Abstract Hypoxia-inducible factor-2α (HIF-2α) is a transcription factor that frequently
accumulates in clear cell renal cell carcinoma (ccRCC), resulting in constitutive activation of …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Due to the adverse effects of erythropoietin (EPO) on cancer patient survival, it is necessary
to develop new agents that can be used to efficiently manage and treat cancer‐related …

Background Vadadustat is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor,
a class of drugs that stabilize HIF and stimulate erythropoietin and red-cell production …

Immunological niches are focal sites of immune activity that can have varying
microenvironmental features. Hypoxia is a feature of physiological and pathological …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

The key regulators of the transcriptional response to hypoxia and inflammation (hypoxia
inducible factor, HIF, and nuclear factor-kappa B, NF-κB, respectively) are evolutionarily …

Distinct regions harboring cancer stem cells (CSCs) have been identified within the
microenvironment of various tumors, and as in the case of their healthy counterparts, these …