[HTML][HTML] Liquid–liquid phase separation in tumor biology
X Tong, R Tang, J Xu, W Wang, Y Zhao, X Yu… - Signal transduction and …, 2022 - nature.com
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
D Overwijn, M Hondele - Trends in Biochemical Sciences, 2023 - cell.com
RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can …
[HTML][HTML] KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer
L Yao, Q Hao, M Wang, Y Chen, H Cao, Q Zhang, K Yu… - Oncogene, 2023 - nature.com
Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer subtype and
accounts for approximately 15–20% of breast cancer cases. In this study, we identified …
accounts for approximately 15–20% of breast cancer cases. In this study, we identified …
The Story of RNA Unfolded: The Molecular Function of DEAD-and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles
K Dörner, M Hondele - Annual Review of Biochemistry, 2024 - annualreviews.org
DEAD-and DExH-box ATPases (DDX/DHXs) are abundant and highly conserved cellular
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
[PDF][PDF] The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
Alphaviruses are a large group of re-emerging arthropod-borne RNA viruses. The compact
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …
viral RNA genomes harbor diverse structures that facilitate replication. These structures can …
[HTML][HTML] The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin …
M Wang, C Yin, Z Wu, X Wang, Q Lin, X Jiang… - Cell Death …, 2023 - nature.com
The second most common male cancer is prostate cancer (PCa), which has a high tendency
for bone metastasis. Long non-coding RNAs, including TMPO-AS1, play a crucial role in …
for bone metastasis. Long non-coding RNAs, including TMPO-AS1, play a crucial role in …
Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease
Z Song, Q Ding, Y Yang - Cellular Signalling, 2023 - Elsevier
The peripheral immune system is thought to influence the pathogenesis of the central
nervous system in Alzheimer's disease (AD) and Parkinson's disease (PD). This study aimed …
nervous system in Alzheimer's disease (AD) and Parkinson's disease (PD). This study aimed …
[HTML][HTML] Aging RNA granule dynamics in neurodegeneration
Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic
causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and …
causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and …
The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis
M Lacroix, H Beauchemin, J Fraszczak, J Ross… - Cancer Research, 2022 - AACR
The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in
several types of human B-cell lymphoma. Females have two active DDX3X alleles and …
several types of human B-cell lymphoma. Females have two active DDX3X alleles and …