DDX3X is an RNA helicase with many functions in RNA metabolism such as mRNA
translation, alternative pre-mRNA splicing and mRNA stability, but also plays a role as a …

Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic
causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and …

The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in
several types of human B-cell lymphoma. Females have two active DDX3X alleles and …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with significant impacts
on patients and their families. Therefore, accurate and early diagnosis of AD is crucial for …

RNA helicases—central enzymes in RNA metabolism—often feature intrinsically disordered
regions (IDRs) that enable phase separation and complex molecular interactions. In the …

The role of sex in health and disease is of central concern to biomedical research, as
reflected by policies from the US National Institutes of Health, European Commission, and …

Summary Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation
(LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation …

DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including
transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation …

Inflammation induced by nonspecific pathogenic or endogenous danger signals is an
essential mechanism of innate immune response. The innate immune responses are rapidly …

Phase separation is a cellular phenomenon where macromolecules aggregate or
segregate, giving rise to biomolecular condensates resembling" droplets" and forming …