The Y-linked gene DDX3Y and its X-linked homolog DDX3X survived the evolution of the
human sex chromosomes from ordinary autosomes. DDX3X encodes a multi-functional RNA …

Biological sex is an important risk factor in cancer, but the underlying cell types and
mechanisms remain obscure. Since tumor development is regulated by the immune system …

Sex chromosomes are a fundamental aspect of sex-biased biology, but the extent to which
homologous XY gene pairs (the gametologs) contribute to sex-biased phenotypes remains …

Background TP53 mutations have a prognostic significance in relapsed and refractory
diffuse large B‐cell lymphoma (rrDLBCL) patients, and their treatment still faces a great …

A Deficiência Intelectual (DI) é uma condição que apresenta grande heterogeneidade
clínica e etiológica, afetando aproximadamente 2-3% dos indivíduos da população mundial …

There is a sex bias in human health and disease and some of these biases could be
explained by the proteins expressed on the X and Y chromosomes. Many of the X …

The sex chromosome-encoded RNA helicases DDX3X and DDX3Y play important roles in
RNA metabolism. Heterozygous mutations of DDX3X frequently occur in cancers and …

DDX3X syndrome is a neurodevelopmental disorder accounting for up to 3% of cases of
intellectual disability (ID) and affecting primarily females. Individuals diagnosed with DDX3X …

The DEAD-box RNA helicase DDX3X is a multifunctional protein involved in RNA
metabolism and stress responses. In this study, we investigated the role of RG/RGG motifs in …

Congenital heart defects (CHDs) are the most common birth defects in humans, affecting
approximately one in one hundred newborns. Our lab has identified several RNA-binding …