DNA was selected over the course of evolution as the ideal molecule for coding and storing
the genetic blueprint of life. One primary driving force for selecting DNA as the repository for …

Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are
closely regulated, and imbalances in the four dNTP pools have genotoxic consequences …

Viruses rely on the metabolic network of the host cell to provide energy and macromolecular
precursors to fuel viral replication. Here we used mass spectrometry to examine the impact …

The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr has previously
been shown to bind to the cellular uracil DNA glycosylase UNG. We show here that the …

The genomes of human and simian immunodeficiency viruses (HIV and SIV) encode the
gag, pol and env genes and contain at least six supplementary open reading frames termed …

To be successful and have the opportunity to replicate properly, a virus has to thwart or, just
the reverse, boost many systems of the host cell. Given that host cells have evolved to …

Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and
simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx …

Large viruses infecting algae or amoebae belong to the NucleoCytoplasmic Large DNA
Viruses (NCLDV) and present genotypic and phenotypic characteristics that have raised …

Following cell entry, the RNA genome of HIV-1 is reverse transcribed into double-stranded
DNA that ultimately integrates into the host-cell genome to establish the provirus. These …

Reverse transcription is a critical step in the life cycle of all retroviruses and related
retrotransposons. This complex process is performed exclusively by the retroviral reverse …