miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay

AS Doghish, MA Ali, SS Elyan, MA Elrebehy… - … -Research and Practice, 2023 - Elsevier
Cervical cancer (CC) is the primary cause of cancer deaths in underdeveloped countries.
The persistence of infection with high-risk human papillomavirus (HPV) is a significant …

Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling

X Rong, W Gao, X Yang, J Guo - Life sciences, 2019 - Elsevier
Aims Hsa_circ_0007534 has been reported to be a novel cancer-related circRNA affecting
multiple cancers. However, little is known about the role of hsa_circ_0007534 in cervical …

Long noncoding RNA SNHG12 promotes the progression of cervical cancer via modulating miR‐125b/STAT3 axis

XJ Jin, XJ Chen, ZF Zhang, WS Hu… - Journal of cellular …, 2019 - Wiley Online Library
Increasing evidence showed that long noncoding RNAs (lncRNAs) played an important role
in the occurrence and development of tumors. To date, lncRNA small nucleolar RNA host …

A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells

Q Sun, Z Yang, P Li, X Wang, L Sun, S Wang… - Cell Death & …, 2019 - nature.com
Abstract microRNAs (miRNAs) play an important role in carcinogenesis. Typically, miRNAs
downregulate the target expression by binding to the 3′ UTR of mRNAs. However, recent …

miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling

X Ji, H Guo, S Yin, H Du - OncoTargets and therapy, 2019 - Taylor & Francis
Objectives Dysregulation of microRNAs (miRNAs) has been recognized as a crucial
biological event in the development of cervical cancer (CC). miR-139-5p was identified as a …

DANCR‐mediated microRNA‐665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway

L Cao, H Jin, Y Zheng, Y Mao, Z Fu, X Li… - Cancer science, 2019 - Wiley Online Library
Emerging evidence has indicated that microRNAs (mi RNA s) play an important role in
cervical cancer (CC). However, the role of miRNA (miR)‐665 in cervical cancer remains …

miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by targeting CYLD

JGP Sanches, Y Xu, IB Yabasin, M Li, Y Lu… - Chemico-biological …, 2018 - Elsevier
Background Cervical cancer is the common gynecological deadly malignancy worldwide.
Here we attempted to evaluate the effects and mechanisms of microRNA-501-5p (miR-501) …

MicroRNA-20a regulates cell proliferation, apoptosis and autophagy by targeting thrombospondin 2 in cervical cancer

Q Zhou, J Dong, R Luo, X Zhou, J Wang… - European journal of …, 2019 - Elsevier
Cervical cancer (CC) is the fourth most frequent malignancy worldwide. MicroRNAs
(miRNAs) can function as potential biomarkers or therapeutic targets in multiple cancers …

CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR

M Dong, P Li, Y Xie, Z Wang… - Drug Development …, 2021 - Wiley Online Library
Circular RNAs are considered to be associated with cancer resistance. This study aims to
investigate the function and mechanism of circMYBL2 in paclitaxel (PTX) resistance of …