Recent studies defined a potentially important role of the microbiome in modulating
pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized …

Simple Summary The survival rates for patients with pancreatic adenocarcinoma are very
low. This dismal prognosis is due in part to late detection and early development of …

Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Importance Although typically impressive, objective responses to immune checkpoint
inhibitors (ICIs) occur in only 12.5% of patients with advanced cancer. The majority of …

Simple Summary Pancreatic ductal adenocarcinoma is one of the deadliest malignancies in
humans. Despite advances in systemic therapy, prognosis still remains poor. However …

Simple Summary The lack of early diagnosis and the absence of suitable biomarkers
coupled with resistance to available therapeutic options render pancreatic cancer one of the …

AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the
ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a …

Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic
components are captured in the autophagosome and degraded in the lysosome. Autophagy …

Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …