Antibiotic use influences outcomes in advanced pancreatic adenocarcinoma patients
C Mohindroo, M Hasanov, JE Rogers, W Dong… - Cancer …, 2021 - Wiley Online Library
Recent studies defined a potentially important role of the microbiome in modulating
pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized …
pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized …
Macrophage and neutrophil interactions in the pancreatic tumor microenvironment drive the pathogenesis of pancreatic cancer
Simple Summary The survival rates for patients with pancreatic adenocarcinoma are very
low. This dismal prognosis is due in part to late detection and early development of …
low. This dismal prognosis is due in part to late detection and early development of …
Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications
Z Bai, Y Peng, X Ye, Z Liu, Y Li, L Ma - Journal of Zhejiang University …, 2022 - Springer
Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
Autophagy and cancer: Basic mechanisms and inhibitor development
Y Hama, Y Ogasawara, NN Noda - Cancer Science, 2023 - Wiley Online Library
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
Human leukocyte antigen class I antigen-processing machinery upregulation by anticancer therapies in the era of checkpoint inhibitors: a review
A Sadagopan, T Michelakos, G Boyiadzis… - JAMA …, 2022 - jamanetwork.com
Importance Although typically impressive, objective responses to immune checkpoint
inhibitors (ICIs) occur in only 12.5% of patients with advanced cancer. The majority of …
inhibitors (ICIs) occur in only 12.5% of patients with advanced cancer. The majority of …
Targeting KRAS in pancreatic ductal adenocarcinoma: The long road to cure
VHF de Jesus, MC Mathias-Machado, JPF de Farias… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma is one of the deadliest malignancies in
humans. Despite advances in systemic therapy, prognosis still remains poor. However …
humans. Despite advances in systemic therapy, prognosis still remains poor. However …
Targeted therapies for pancreatic cancer: overview of current treatments and new opportunities for personalized oncology
C Leroux, G Konstantinidou - Cancers, 2021 - mdpi.com
Simple Summary The lack of early diagnosis and the absence of suitable biomarkers
coupled with resistance to available therapeutic options render pancreatic cancer one of the …
coupled with resistance to available therapeutic options render pancreatic cancer one of the …
AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
JO Rayner, RA Roberts, J Kim, A Poklepovic… - Biochemical …, 2020 - Elsevier
AR12 is a derivative of celecoxib which no-longer acts against COX2 but instead inhibits the
ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a …
ATPase activity of multiple chaperone proteins, in particular GRP78. GRP78 acts as a …
Targeting autophagy as a therapeutic strategy against pancreatic cancer
K Yamamoto, D Iwadate, H Kato, Y Nakai… - Journal of …, 2022 - Springer
Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic
components are captured in the autophagosome and degraded in the lysosome. Autophagy …
components are captured in the autophagosome and degraded in the lysosome. Autophagy …
Understanding the role of autophagy in cancer formation and progression is a real opportunity to treat and cure human cancers
Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …