This review reports in detail the cellular and molecular mechanisms which regulate the bone
remodeling process in relation to oxidative stress (OS), inflammatory factors, and estrogen …

Excess adiposity in childhood may affect bone development, ultimately leading to bone
frailty. Previous reports showing an increased rate of extremity fractures in children with …

Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

As orthopedic and dental implants, polyetheretherketone (PEEK) is expected to be a
common substitute material of titanium (Ti) and its alloys due to its good biocompatibility …

Bone is a complex structure with unique cellular and molecular process in its formation.
Bone tissue regeneration is a well-organized and routine process at the cellular and …

Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair,
because GO can not only enhance the mechanical properties of polymers but also promote …

Methylcatechol (4-MC) is an agonist of various neurotrophic factors, which can upregulate
the expression of Heme oxygenase 1 (HO-1) protein by activating nuclear factor erythroid 2 …

Aging is a multi-faceted process caused by the accumulation of cellular damage over time,
associated with a gradual reduction of physiological activities in cells and organs. This …

Icariin is a biologically active substance in Epimedii herba that is used for the treatment of
neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of …

Polyphenolic compounds are a diverse group of natural compounds that interact with
various cellular proteins responsible for cell survival, differentiation, and apoptosis …