Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Obesity-associated inflammation is a systemic process that affects all metabolic organs.
Prominent among these is adipose tissue, where cells of the innate and adaptive immune …

Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant,
nosocomial pathogens that cause health care–associated infections. We developed a …

Trained immunity is a de facto memory for innate immune responses, leading to long-term
functional reprogramming of innate immune cells. In physiological conditions, trained …

Infections and vaccines can induce enhanced long-term responses in innate immune cells,
establishing an innate immunological memory termed trained immunity. Here, we show that …

Neutrophils are classically characterized as merely reactive innate effector cells. However,
the microbiome is known to shape the education and maturation process of neutrophils …

The tumor suppressor p53 controls cell fate decisions and prevents malignant
transformation, but its functions in antiviral immunity remain unclear. Here, we demonstrate …

For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Energy metabolism maintains the activation of intracellular and intercellular signal
transduction, and plays a crucial role in immune response. Under environmental stimulation …