Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The
ideal method for 5mC localization would be both nondestructive of DNA and direct, without …

Labeling of nucleic acids is required for many studies aiming to elucidate their functions and
dynamics in vitro and in cells. Out of the numerous labeling concepts that have been …

In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …

S‐Adenosylmethionine‐dependent methyltransferases are versatile tools for the specific
alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is …

Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved
proteins in living organisms. AHCY catalyzes the reversible break of S …

Epigenetics is the study of heritable changes in gene expression without changing the DNA
sequence-a change in phenotype without a change in genotype. Epigenetic abnormalities …