[HTML][HTML] Interactome-based approaches to human disease

M Caldera, P Buphamalai, F Müller… - Current Opinion in Systems …, 2017 - Elsevier
Recent advances in high-throughput technologies have created exciting opportunities for
systematically investigating the molecular basis of human disease. In addition to a growing …

[HTML][HTML] Predicting lncRNA–miRNA interactions based on interactome network and graphlet interaction

L Zhang, T Liu, H Chen, Q Zhao, H Liu - Genomics, 2021 - Elsevier
In the development and treatment of many human diseases, the regulatory roles between
lncRNAs and miRNAs are important, but much remains unknown about them; moreover …

Exploring the structure and function of temporal networks with dynamic graphlets

Y Hulovatyy, H Chen, T Milenković - Bioinformatics, 2015 - academic.oup.com
Motivation: With increasing availability of temporal real-world networks, how to efficiently
study these data? One can model a temporal network as a single aggregate static network …

From homogeneous to heterogeneous network alignment via colored graphlets

S Gu, J Johnson, FE Faisal, T Milenković - Scientific reports, 2018 - nature.com
Network alignment (NA) compares networks with the goal of finding a node mapping that
uncovers highly similar (conserved) network regions. Existing NA methods are …

Prediction of potential small molecule-associated microRNAs using graphlet interaction

NN Guan, YZ Sun, Z Ming, JQ Li, X Chen - Frontiers in pharmacology, 2018 - frontiersin.org
MicroRNAs (miRNAs) have been proved to be targeted by the small molecules recently,
which made using small molecules to target miRNAs become a possible therapy for human …

MFIDMA: a multiple information integration model for the prediction of drug–miRNA associations

YJ Guan, CQ Yu, Y Qiao, LP Li, ZH You, ZH Ren, YC Li… - Biology, 2022 - mdpi.com
Simple Summary Predicting the possible associations between drugs and miRNAs would
provide new perspectives on miRNA therapeutics research and drug discovery. However …

GIMDA: graphlet interaction‐based MiRNA‐disease association prediction

X Chen, NN Guan, JQ Li, GY Yan - Journal of cellular and …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) have been confirmed to be closely related to various human complex
diseases by many experimental studies. It is necessary and valuable to develop powerful …

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients

M Teymoori-Rad, SH Mozhgani, M Zarei-Ghobadi… - Gene, 2019 - Elsevier
Given the multifactorial state of autoimmune complex diseases such as multiple sclerosis
(MS), it is not clear if different risk factors act jointly or independently. Despite intensive …

Predicting disease-related genes by path structure and community structure in protein–protein networks

K Hu, JB Hu, L Tang, J Xiang, JL Ma… - Journal of Statistical …, 2018 - iopscience.iop.org
Network-based computational approaches in the prediction of genes that are associated
with diseases are of considerable importance in uncovering the molecular basis of human …

Identification of miRNA-small molecule associations by continuous feature representation using auto-encoders

I Abdelbaky, H Tayara, KT Chong - Pharmaceutics, 2021 - mdpi.com
MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in the body and
affect various diseases, including cancers. Controlling miRNAs with small molecules is …