Water pollution caused by widely used agricultural pesticide chlorpyrifos (CPF) has aroused
extensive public concern. While previous studies have reported on toxic effect of CPF on …

Major depressive disorder is a global psychiatric condition characterized by persistent low
mood and anhedonia, which seriously jeopardizes the physical and mental well-being of …

Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Background and purpose The paper observes regulation of the expression levels of NLRP3
and TLR4 in hippocampal CA1 neurons in CUMS mice by aerobic exercise with constructing …

The escalating prevalence of neurodegenerative diseases (NDDs) within an aging global
population presents a pressing challenge. The multifaceted pathophysiological mechanisms …

Decreased hippocampal synaptic plasticity is an important pathological change in stress-
related mood disorders, including major depressive disorder. However, the underlying …

The core symptoms of depression are anhedonia and persistent hopelessness. Selective
serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for …

Background Depression is a common mental illness characterised by abnormal and
depressed emotions. Total paeony glycoside (TPG) is a naturally active saponin extracted …

Depression is the most prevalent mental disorder, affecting more than 300 million adults
worldwide each year, which can lead to serious economic and social problems …

Simple Summary Depression is a significant public health problem, and its pathogenesis is
associated with inflammation in the central nervous system. In this study, we investigated the …