Hyphal growth in human fungal pathogens and its role in virulence

A Brand - International journal of microbiology, 2012 - Wiley Online Library
Most of the fungal species that infect humans can grow in more than one morphological form
but only a subset of pathogens produce filamentous hyphae during the infection process …

Aspergillus‐Associated Airway Disease, Inflammation, and the Innate Immune Response

SH Chotirmall, M Al-Alawi, B Mirkovic… - BioMed research …, 2013 - Wiley Online Library
Aspergillus moulds exist ubiquitously as spores that are inhaled in large numbers daily.
Whilst most are removed by anatomical barriers, disease may occur in certain …

Evolutionary compromises in fungal fitness: hydrophobins can hinder the adverse dispersal of conidiospores and challenge their survival

F Cai, R Gao, Z Zhao, M Ding, S Jiang, C Yagtu… - The ISME …, 2020 - academic.oup.com
Fungal evolutionary biology is impeded by the scarcity of fossils, irregular life cycles,
immortality, and frequent asexual reproduction. Simple and diminutive bodies of fungi …

Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-γ release

M Bouzani, M Ok, A McCormick, F Ebel… - The Journal of …, 2011 - journals.aai.org
Despite the strong interest in the NK cell-mediated immunity toward malignant cells and
viruses, there is a relative lack of data on the interplay between NK cells and filamentous …

Combination therapy to treat fungal biofilm-based infections

J Tits, BPA Cammue, K Thevissen - International Journal of Molecular …, 2020 - mdpi.com
An increasing number of people is affected by fungal biofilm-based infections, which are
resistant to the majority of currently-used antifungal drugs. Such infections are often caused …

Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation

F Hillmann, S Novohradská, DJ Mattern… - Environmental …, 2015 - Wiley Online Library
Filamentous fungi represent classical examples for environmentally acquired human
pathogens whose major virulence mechanisms are likely to have emerged long before the …

Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment

E Maurer, C Hörtnagl, M Lackner, D Grässle… - Medical …, 2019 - academic.oup.com
Mucorales can cause cutaneous to deep-seated infections, mainly in the
immunocompromised host, resulting in high mortality rates due to late and inefficient …

The eukaryome: diversity and role of microeukaryotic organisms associated with animal hosts

J del Campo, D Bass, PJ Keeling - Functional Ecology, 2020 - Wiley Online Library
Awareness of the roles that host‐associated microbes play in host biology has escalated in
recent years. However, microbiome studies have focused essentially on bacteria, and …

Interaction of the pathogenic mold Aspergillus fumigatus with lung epithelial cells

N Osherov - Frontiers in microbiology, 2012 - frontiersin.org
Aspergillus fumigatus is an opportunistic environmental mold that can cause severe allergic
responses in atopic individuals and poses a life-threatening risk for severely …

Characterization of the velvet regulators in Aspergillus fumigatus

HS Park, Ö Bayram, GH Braus, SC Kim… - Molecular …, 2012 - Wiley Online Library
Fungal development and secondary metabolism is intimately associated via activities of the
fungi‐specific velvet family proteins. Here we characterize the four velvet regulators in the …