Skin barrier function and the microbiome

HJ Lee, M Kim - International journal of molecular sciences, 2022 - mdpi.com
Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …

Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis

M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

The role of Th17-related cytokines in atopic dermatitis

M Sugaya - International journal of molecular sciences, 2020 - mdpi.com
T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of
various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases …

Aryl hydrocarbon receptor in atopic dermatitis and psoriasis

M Furue, A Hashimoto-Hachiya, G Tsuji - International journal of …, 2019 - mdpi.com
The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive
sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin …

Regulation of skin barrier function via competition between AHR axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 axis: pathogenic and therapeutic implications in atopic …

M Furue - Journal of Clinical Medicine, 2020 - mdpi.com
Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction, and chronic
pruritus. As the anti-interleukin-4 (IL-4) receptor α antibody dupilumab improves all three …

[HTML][HTML] Skin microbiome in atopic dermatitis

SM Edslev, T Agner, PS Andersen - Acta dermato-venereologica, 2020 - ncbi.nlm.nih.gov
Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that
includes imbalanced immune system signalling, impaired skin barrier and enhanced …

Advances in our understanding of canine atopic dermatitis

R Marsella - Veterinary dermatology, 2021 - Wiley Online Library
Canine atopic dermatitis (cAD) is a genetically inherited clinical syndrome that
encompasses a diversity of mechanisms and can have a variety of triggers. Development of …

Cytokine-mediated crosstalk between keratinocytes and T cells in atopic dermatitis

M Humeau, K Boniface, C Bodet - Frontiers in immunology, 2022 - frontiersin.org
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier
dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus …

A new insight into the potential role of tryptophan-derived AhR ligands in skin physiological and pathological processes

M Szelest, K Walczak, T Plech - International journal of molecular …, 2021 - mdpi.com
The aryl hydrocarbon receptor (AhR) plays a crucial role in environmental responses and
xenobiotic metabolism, as it controls the transcription profiles of several genes in a ligand …

A journey on the skin microbiome: pitfalls and opportunities

D Pistone, G Meroni, S Panelli, E D'Auria… - International journal of …, 2021 - mdpi.com
The human skin microbiota is essential for maintaining homeostasis and ensuring barrier
functions. Over the years, the characterization of its composition and taxonomic diversity has …