Cellular energy is primarily provided by the oxidative degradation of nutrients coupled with
mitochondrial respiration, in which oxygen participates in the mitochondrial electron …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Glycolytic intermediary metabolites such as fructose-1, 6-bisphosphate can serve as signals,
controlling metabolic states beyond energy metabolism. However, whether glycolytic …

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body
energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy …

The first identified biochemical hallmark of tumor cells was a shift in glucose metabolism
from oxidative phosphorylation to aerobic glycolysis. We now know that much of this …

AMPK is a serine/threonine protein kinase, which serves as an energy sensor in all
eukaryotic cell types. Published studies indicate that AMPK activation strongly suppresses …

The metabolic syndrome is a constellation of metabolic disorders including obesity,
hypertension, and insulin resistance, components which are risk factors for the development …

AMP-activated protein kinase (AMPK) is a cellular energy sensor activated by metabolic
stresses that either inhibit ATP synthesis or accelerate ATP consumption. Activation of AMPK …