[HTML][HTML] Physical Exercise as Disease-Modifying Alternative against Alzheimer's Disease: A Gut–Muscle–Brain Partnership

D Cutuli, D Decandia, G Giacovazzo… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a common cause of dementia characterized by
neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms …

[HTML][HTML] Therapeutic potential of targeting mitochondria for Alzheimer's disease treatment

A Atlante, G Amadoro, V Latina, D Valenti - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, is
characterized by memory and cognitive impairment and by the accumulation in the brain of …

[HTML][HTML] Pre-and post-treatment of α-Tocopherol on cognitive, synaptic plasticity, and mitochondrial disorders of the hippocampus in icv-streptozotocin-induced …

F Nabavi Zadeh, M Nazari, A Amini, S Adeli… - Frontiers in …, 2023 - frontiersin.org
Objective Most dementia cases in the elderly are caused by Alzheimer's disease (AD), a
complex, progressive neurological disease. Intracerebroventricular (ICV) administration of …

Pathological impact of tau proteolytical process on neuronal and mitochondrial function: a crucial role in alzheimer's disease

MA Olesen, RA Quintanilla - Molecular Neurobiology, 2023 - Springer
Tau protein plays a pivotal role in the central nervous system (CNS), participating in
microtubule stability, axonal transport, and synaptic communication. Research interest has …

Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype

M Zhu, B Xiao, T Xue, S Qin, J Ding, Y Wu, Q Tang… - Brain, 2023 - academic.oup.com
Alzheimer's disease, the most common cause of dementia, is a chronic degenerative
disease with typical pathological features of extracellular senile plaques and intracellular …

Early time course of oxidative stress in hippocampal synaptosomes and cognitive loss following impaired insulin signaling in rats: Development of sporadic …

MA Ansari, MS Rao, A Al-Jarallah, FM Babiker - Brain Research, 2023 - Elsevier
Oxidative stress, caused by impaired insulin signaling, plays a pivotal role in the
pathogenesis of sporadic Alzheimer's disease (sAD). We investigated the oxidative stress …

[HTML][HTML] Impaired insulin signaling alters mediators of hippocampal synaptic dynamics/plasticity: a possible mechanism of hyperglycemia-induced cognitive …

MA Ansari, A Al-Jarallah, FA Babiker - Cells, 2023 - mdpi.com
Simple Summary An early time course study of the proteins associated to synaptic dynamics
and cognitive behavior. Study evaluated the expression levels and activation state of …

Cognitive dysfunction and increased phosphorylated tau are associated with reduced O‐GlcNAc signaling in an aging mouse model of metabolic syndrome

S Gupta, SKA Jinka, S Khanal… - Journal of …, 2023 - Wiley Online Library
Metabolic syndrome (MetS), characterized by hyperglycemia, obesity, and hyperlipidemia,
can increase the risk of developing late‐onset dementia. Recent studies in patients and …

[HTML][HTML] Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer's disease-like pathology in hippocampal neuronal cells via the blocking of Ca2+/Calpain/Cdk5 …

J Park, J Won, E Yang, J Seo, J Cho, JB Seong… - Scientific Reports, 2024 - nature.com
Oxidative stress plays an essential role in the progression of Alzheimer's disease (AD), the
most common age-related neurodegenerative disorder. Streptozotocin (STZ)-induced …

[HTML][HTML] Shen Qi Wan ameliorates learning and memory impairment induced by STZ in AD rats through PI3K/AKT pathway

J Huang, Z Xu, H Chen, Y Lin, J Wei, S Wang, H Yu… - Brain Sciences, 2022 - mdpi.com
Alzheimer's disease is the most common form of neurodegenerative disease, and increasing
evidence shows that insulin signaling has crucial roles in AD initiation and progression. In …