Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function
R Siekmeier, T Grammer… - Journal of cardiovascular …, 2008 - journals.sagepub.com
Vascular endothelium plays a crucial role in ensuring normal function and morphology of
blood vessels, and many risk factors of atherosclerosis act via their effects on endothelial …
blood vessels, and many risk factors of atherosclerosis act via their effects on endothelial …
RAAS: a convergent player in ischemic heart failure and cancer
TC Garcia-Garduño, JR Padilla-Gutierrez… - International journal of …, 2021 - mdpi.com
The current global prevalence of heart failure is estimated at 64.34 million cases, and it is
expected to increase in the coming years, especially in countries with a medium-low …
expected to increase in the coming years, especially in countries with a medium-low …
[HTML][HTML] Qiliqiangxin attenuates cardiac remodeling via inhibition of TGF-β1/Smad3 and NF-κB signaling pathways in a rat model of myocardial infarction
A Han, Y Lu, Q Zheng, J Zhang, YZ Zhao… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Qiliqiangxin (QL), a traditional Chinese medicine, has been
demonstrated to be effective and safe for the treatment of chronic heart failure. Left …
demonstrated to be effective and safe for the treatment of chronic heart failure. Left …
Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF‐β1 and HIF‐1α in Ang II‐mediated fibrosis after myocardial infarction
X Sui, H Wei, D Wang - Journal of Cellular and Molecular …, 2015 - Wiley Online Library
Transforming growth factor (TGF)‐β1 is a known factor in angiotensin II (Ang II)‐mediated
cardiac fibrosis after myocardial infarction (MI). Hypoxia inducible factor‐1 (Hif‐1α) was …
cardiac fibrosis after myocardial infarction (MI). Hypoxia inducible factor‐1 (Hif‐1α) was …
Pharmacokinetic Evaluation of Improved Oral Bioavailability of Valsartan: Proliposomes Versus Self-Nanoemulsifying Drug Delivery System
V Nekkanti, Z Wang, GV Betageri - AAPS PharmSciTech, 2016 - Springer
The objective of this study was to develop proliposomes and self-nanoemulsifying drug
delivery system (SNEDDS) for a poorly bioavailable drug, valsartan, and to compare their in …
delivery system (SNEDDS) for a poorly bioavailable drug, valsartan, and to compare their in …
Radioiodinated Procainamide as Radiotracer for Myocardial Perfusion Imaging in Mice
This work focuses on the synthesis and preliminary biological evaluation of [125I]
iodoprocainamide ([125I] iodoPA) as a potential heart-imaging agent.[125I] iodoPAwas …
iodoprocainamide ([125I] iodoPA) as a potential heart-imaging agent.[125I] iodoPAwas …
Preparation and appraisal of self-assembled valsartan-loaded amalgamated Pluronic F127/Tween 80 polymeric micelles: Boosted cardioprotection via regulation of …
HM Aboud, MO Mahmoud… - Journal of drug …, 2020 - Taylor & Francis
This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …
Radioiodinated azilsartan as a new highly selective radiotracer for myocardial perfusion imaging
Azilsartan (AZ) was labeled with 131 I using Chloramine-T as oxidizing agent. Factors
affecting the labeling efficiency were systematically studied, and optimum conditions were …
affecting the labeling efficiency were systematically studied, and optimum conditions were …
Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice
This study focuses on the synthesis and preliminary bio-evaluation of [99mTc]-technetium
tricarbonyl procainamide ([99mTc]-technetium tricarbony PA) as a viable cardiac imaging …
tricarbonyl procainamide ([99mTc]-technetium tricarbony PA) as a viable cardiac imaging …
Medicinal chemistry of drugs used in diabetic cardiomyopathy
E Adeghate, H Kalasz, G Veress… - Current medicinal …, 2010 - ingentaconnect.com
Diabetes mellitus is a common disease and contributes to a high degree of morbidity and
mortality. Cardiovascular complications, including diabetic cardiomyopathy are major …
mortality. Cardiovascular complications, including diabetic cardiomyopathy are major …