Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function

R Siekmeier, T Grammer… - Journal of cardiovascular …, 2008 - journals.sagepub.com
Vascular endothelium plays a crucial role in ensuring normal function and morphology of
blood vessels, and many risk factors of atherosclerosis act via their effects on endothelial …

RAAS: a convergent player in ischemic heart failure and cancer

TC Garcia-Garduño, JR Padilla-Gutierrez… - International journal of …, 2021 - mdpi.com
The current global prevalence of heart failure is estimated at 64.34 million cases, and it is
expected to increase in the coming years, especially in countries with a medium-low …

[HTML][HTML] Qiliqiangxin attenuates cardiac remodeling via inhibition of TGF-β1/Smad3 and NF-κB signaling pathways in a rat model of myocardial infarction

A Han, Y Lu, Q Zheng, J Zhang, YZ Zhao… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Qiliqiangxin (QL), a traditional Chinese medicine, has been
demonstrated to be effective and safe for the treatment of chronic heart failure. Left …

Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF‐β1 and HIF‐1α in Ang II‐mediated fibrosis after myocardial infarction

X Sui, H Wei, D Wang - Journal of Cellular and Molecular …, 2015 - Wiley Online Library
Transforming growth factor (TGF)‐β1 is a known factor in angiotensin II (Ang II)‐mediated
cardiac fibrosis after myocardial infarction (MI). Hypoxia inducible factor‐1 (Hif‐1α) was …

Pharmacokinetic Evaluation of Improved Oral Bioavailability of Valsartan: Proliposomes Versus Self-Nanoemulsifying Drug Delivery System

V Nekkanti, Z Wang, GV Betageri - AAPS PharmSciTech, 2016 - Springer
The objective of this study was to develop proliposomes and self-nanoemulsifying drug
delivery system (SNEDDS) for a poorly bioavailable drug, valsartan, and to compare their in …

Radioiodinated Procainamide as Radiotracer for Myocardial Perfusion Imaging in Mice

MH Sanad, HM Eyssa, FA Marzook, AB Farag… - Pharmaceutical …, 2023 - Springer
This work focuses on the synthesis and preliminary biological evaluation of [125I]
iodoprocainamide ([125I] iodoPA) as a potential heart-imaging agent.[125I] iodoPAwas …

Preparation and appraisal of self-assembled valsartan-loaded amalgamated Pluronic F127/Tween 80 polymeric micelles: Boosted cardioprotection via regulation of …

HM Aboud, MO Mahmoud… - Journal of drug …, 2020 - Taylor & Francis
This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …

Radioiodinated azilsartan as a new highly selective radiotracer for myocardial perfusion imaging

MH Sanad, FA Marzook, SFA Rizvi, AB Farag… - Radiochemistry, 2021 - Springer
Azilsartan (AZ) was labeled with 131 I using Chloramine-T as oxidizing agent. Factors
affecting the labeling efficiency were systematically studied, and optimum conditions were …

Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice

MH Sanad, FA Marzook, AB Farag, SK Mandal… - Radiochimica …, 2022 - degruyter.com
This study focuses on the synthesis and preliminary bio-evaluation of [99mTc]-technetium
tricarbonyl procainamide ([99mTc]-technetium tricarbony PA) as a viable cardiac imaging …

Medicinal chemistry of drugs used in diabetic cardiomyopathy

E Adeghate, H Kalasz, G Veress… - Current medicinal …, 2010 - ingentaconnect.com
Diabetes mellitus is a common disease and contributes to a high degree of morbidity and
mortality. Cardiovascular complications, including diabetic cardiomyopathy are major …