Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …

Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal
adenocarcinoma (PDA). However, the immunomodulatory function of Treg cells in PDA is …

CD28 and CTLA-4 are both important stimulatory receptors for the regulation of T cell
activation. Because receptors share common ligands, B7. 1 and B7. 2, the expression and …

Summary Foxp3+ T regulatory (Treg) cells regulate immune responses and maintain self-
tolerance. Recent work shows that Treg cells are comprised of many subpopulations with …

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness.
Analysis of disease tolerance pathways could provide new approaches for treating …

Sustained access to nutrients is a fundamental biological need, especially for proliferating
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by
hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to …

Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …