Structural aspects of chemical modifications in the MHC-restricted immunopeptidome; Implications for immune recognition

T Sandalova, BM Sala, A Achour - Frontiers in Chemistry, 2022 - frontiersin.org
Significant advances in mass-spectroscopy (MS) have made it possible to investigate the
cellular immunopeptidome, a large collection of MHC-associated epitopes presented on the …

Diphthamide–a conserved modification of eEF2 with clinical relevance

R Schaffrath, U Brinkmann - Trends in Molecular Medicine, 2024 - cell.com
Diphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2),
assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis …

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication

S Krieg, F Pott, L Potthoff, M Verheirstraeten… - Cellular and Molecular …, 2023 - Springer
Replication of viruses requires interaction with host cell factors and repression of innate
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating …

Mutational analysis of structural proteins of SARS-CoV-2

S Jakhmola, O Indari, D Kashyap, N Varshney, A Das… - Heliyon, 2021 - cell.com
SARS-CoV-2 transmissibility is higher than that of other human coronaviruses; therefore, it
poses a threat to the populated communities. We investigated mutations among envelope …

Network-based analysis of OMICs data to understand the HIV–host interaction

S Ivanov, A Lagunin, D Filimonov… - Frontiers in …, 2020 - frontiersin.org
The interaction of human immunodeficiency virus with human cells is responsible for all
stages of the viral life cycle, from the infection of CD4+ cells to reverse transcription …

Post-translational modifications of retroviral HIV-1 gag precursors: an overview of their biological role

C Bussienne, R Marquet, JC Paillart… - International Journal of …, 2021 - mdpi.com
Protein post-translational modifications (PTMs) play key roles in eukaryotes since they finely
regulate numerous mechanisms used to diversify the protein functions and to modulate their …

HIV-1 virological synapse formation enhances infection spread by dysregulating Aurora Kinase B

JW Bruce, E Park, C Magnano, M Horswill… - PLoS …, 2023 - journals.plos.org
HIV-1 spreads efficiently through direct cell-to-cell transmission at virological synapses
(VSs) formed by interactions between HIV-1 envelope proteins (Env) on the surface of …

The phosphorylation of the N protein could affect PRRSV virulence in vivo

Y Chen, Z Yu, H Yi, Y Wei, X Han, Q Li, C Ji… - Veterinary …, 2019 - Elsevier
The porcine respiratory and reproductive syndrome virus (PRRSV) nucleocapsid (N) protein
is a multiphosphorylated protein. It has been proved that the phosphorylation of N protein …

[HTML][HTML] First report of computational protein–ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients

F Ghasabi, A Hashempour, N Khodadad… - … and Biophysics Reports, 2022 - Elsevier
Background Iran has recently included integrase (INT) inhibitors (INTIs) in the first‐line
treatment regimen in human immunodeficiency virus (HIV)-infected patients. However, there …

[HTML][HTML] FusionAI: predicting fusion breakpoint from DNA sequence with deep learning

P Kim, H Tan, J Liu, M Yang, X Zhou - Iscience, 2021 - cell.com
Identifying the molecular mechanisms related to genomic breakage is an important goal of
cancer mechanism studies. Among diverse locations of structural variants, fusion genes …