Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and
inactive, are a central component in envenoming. These are responsible for disrupting the …

Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we
reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular …

The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …

Altered epidermal differentiation along with increased keratinocyte proliferation is a
characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the
differentiation of T helper 17 (TH17) cells. However, the exact enzymes and lipid metabolites …

Abstract Calcium ions (Ca 2+) and the complex regulatory system governed by Ca 2+
signaling have been described to be of crucial importance in numerous aspects related to …

One of the most critical steps in cereal threshing is the ease with which seeds are detached
from sticky glumes. Naked grains with low glume coverage have dramatically increased …

Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted
phospholipase A 2 (sPLA 2-IIA) prevents bacterial infection by degrading bacterial …