Objectives The aim of this study was to provide a comprehensive overview of the clinically
relevant anatomical and histological aspects of the development of the human pancreas …

The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then
throughout the embryo to establish circulatory networks that further acquire organ-specific …

The overall conservation between mouse and human pancreatic development, islet
physiology and etiology of diabetes encourages the translation of novel β cell replacement …

Aims/hypothesis Islet transplantation is a promising cell therapy for patients with diabetes,
but it is currently limited by the reliance upon cadaveric donor tissue. We previously …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …

In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergence
from a bipotent duct/endocrine progenitor pool, which resides in the “trunk epithelium.” Major …

Most tooth‐bearing non‐mammalian vertebrates have the capacity to replace their teeth
throughout life. This capacity was lost in mammals, which replace their teeth only once at …

Organoids can be regarded as a beneficial tool for discovery of new therapeutics for
diabetes and/or maturation of pancreatic progenitors (PP) towards β cells. Here, we devised …

Background Over the last decades, various approaches have been explored to restore
sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new …

Diabetes mellitus results from disturbed glucose homeostasis due to an absolute (type 1) or
relative (type 2) deficiency of insulin, a peptide hormone almost exclusively produced by the …