Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor
prognosis. There is an urgent need to identify new therapeutic targets and also understand …

Brain metastases (BM) are the most common brain neoplasm in adults. Current BM
therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for …

Simple Summary Triple-negative breast cancer (TNBC) has been associated with worse
prognoses due to the limited treatment options. Thus, there is a need to characterise new …

Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression,
but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the …

Breast cancer is the most common cancer diagnosed and is the second leading cause of
cancer death among women in the US. For breast cancer, early diagnosis and efficient …

Recurrence of therapy-resistant tumors is a principal problem in solid tumor oncology,
particularly in ovarian cancer. Despite common complete responses to first line, platinum …

Background The aberrant expression of sperm-associated antigen 9 (SPAG9) is associated
with numerous cancers, including hepatocellular carcinoma (HCC). The exploration of …

Paclitaxel (PTX) is a microtubule-stabilizing agent widely used to treat breast cancer.
Nevertheless, the low solubility of the drug and the side effects of commercial formulations …

There are different views of how the immune system participates in the reaction to cancer.
Here, we evaluated expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 …

Abstract Sperm-associated antigen 9 (SPAG9) is a new member of cancer testis antigen and
belongs to c-Jun NH2-terminal kinase (JNK) interacting protein (JIP) family. SPAG9 is highly …