The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular
proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Formation of mature bone-resorbing cells through osteoclastogenesis is required for the
continuous remodeling and repair of bone tissue. In aging and disease this process may …

Glycoprotein VI (GPVI) mediates collagen-induced platelet activation after vascular damage
and is an important contributor to the onset of thrombosis, heart attack, and stroke. Animal …

The COVID-19 pandemic has wielded an enormous pressure on global health care systems,
economics and politics. Ongoing vaccination campaigns effectively attenuate viral …

Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and
regulate their cellular differentiation. Receptor activator for NF-κB ligand (RANKL or …

The collectins family encompasses several collagenous Ca 2+-dependent defense lectins
that are described as pathogen recognition molecules. They play an important role in both …