Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …

Growth hormone is widely used clinically to promote growth and anabolism and for other
purposes. Its actions are mediated via the growth hormone receptor, both directly by tyrosine …

Several components of the GH axis are involved in tumor progression, and GH-induced
intracellular signaling has been strongly associated with breast cancer susceptibility in …

Preclinical evidence that targeting the insulin-like growth factor receptor (IGF-IR) is effective
in cancer treatment has been accumulating for almost two decades. Efforts to develop drugs …

It is universally accepted that diets rich in fruit and vegetables lead to reduction in the risk of
common forms of cancer and are useful in cancer prevention. Indeed edible vegetables and …

A growing body of recent literature indicates that in addition to an essential role in growth
and development, growth hormone may also play a more sinister role in oncogenic …

Epithelium mammary carcinoma is a cancer with a high death rate among women. One
factor having a significant impact on metastasis is cell migration. The aim of this study was to …

Emerging evidence links the growth hormone (GH)-insulin-like growth factor-1 (IGF1)
endocrine axis to cancer development. While this putative correlation is of major …

The superior ovarian nerve (SON) arrives at the ovary through the suspensory ligament and
innervates mainly the ovarian stroma. Most neurones from which the SON fibres originate …

The growth hormone–insulin-like growth factor-I (GH–IGF-I) axis plays a fundamental role in
the development of the breast. The maintenance of breast tissue architecture is aided by its …