[HTML][HTML] Ligand-targeted delivery of photosensitizers for cancer treatment

P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge… - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is a promising cancer treatment which involves a
photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which …

[HTML][HTML] Targeted cancer phototherapy using phthalocyanine–anticancer drug conjugates

CC Rennie, RM Edkins - Dalton Transactions, 2022 - pubs.rsc.org
Phototherapy, the use of light to selectively ablate cancerous tissue, is a compelling
prospect. Phototherapy is divided into two major domains: photodynamic and photothermal …

[HTML][HTML] Recent progress in phthalocyanine-polymeric nanoparticle delivery systems for cancer photodynamic therapy

W Borzęcka, A Domiński, M Kowalczuk - Nanomaterials, 2021 - mdpi.com
This perspective article summarizes the last decade's developments in the field of
phthalocyanine (Pc)-polymeric nanoparticle (NP) delivery systems for cancer photodynamic …

Electrochemical Iodoamination of Indoles Using Unactivated Amines

N Lei, Y Shen, Y Li, P Tao, L Yang, Z Su… - Organic Letters, 2020 - ACS Publications
An environmentally friendly electrochemical approach for iodoamination of various indole
derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles …

Vincristine-loaded polymeric corona around gold nanorods for combination (chemo-photothermal) therapy of oral squamous carcinoma

WM Darwish, AS Abdoon, MS Shata… - Reactive and Functional …, 2020 - Elsevier
In this work, we describe the design of a novel combination (chemo-photothermal)
therapeutic model comprising vincristine (VCR) as phytochemical anticancer and plasmonic …

Polymers for enhanced photodynamic cancer therapy: Phthalocyanines as a photosensitzer model

W Darwish - Polymers for Advanced Technologies, 2021 - Wiley Online Library
The use of photosensitizers (PSs) in cancer therapy opened new avenues for developing
minimally‐invasive treatment of cancer. However, problems related to lack of …

Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution

WM Darwish, NA Bayoumi, NH Ebeid - Biopolymers, 2022 - Wiley Online Library
Two nanoformulations with mucoadhesive properties and brain‐targeting mechanisms were
designed to deliver the anti‐Parkinson's drug, ropinirole hydrochloride (RH). In the first …

A novel gold-polymer-antibody conjugate for targeted (radio-photothermal) treatment of HepG2 cells

WM Darwish, NA Bayoumi… - Journal of …, 2023 - Taylor & Francis
Localization of the near-infrared (NIR) plasmonic nanoparticles at the tumor sites is essential
for safe and efficient photothermal therapy of cancer. In this work, two biocompatible …

Pegylation–in search of balance and enhanced bioavailability

D Łażewski, M Murias… - Journal of Medical Science, 2022 - jms.ump.edu.pl
In the process of finding better therapeutics, thousands of new molecules are synthesised
every day. Many of these can be poorly soluble in water, leading to a potentially promising …

Intranasal Radioiodinated Ferulic Acid Polymeric Micelles as the First Nuclear Medicine Imaging Probe for ETRA Brain Receptor

H Fayez, A Selim, R Shamma… - Current …, 2024 - ingentaconnect.com
Introduction: The aim of this work was to prepare a selective nuclear medicine imaging
probe for the Endothelin 1 receptor A in the brain. Material and Methods: Ferulic acid (an …