Background: Fetal macrosomia, defined as a birth weight≥ 4,000 g, may affect 12% of
newborns of normal women and 15-45% of newborns of women with gestational diabetes …

In this review, the potential causes and consequences of adult height, a measure of
cumulative net nutrition, in modern populations are summarized. The mechanisms linking …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …

DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …

The organization of eukaryotic genomes into chromatin provides challenges for the cell to
accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

Background Alzheimer's disease affects~ 13% of people in the United States 65 years and
older, making it the most common neurodegenerative disorder. Recent work has identified …

A growing body of evidence points towards epigenetic mechanisms being responsible for a
wide range of biological phenomena, from the plasticity of plant growth and development to …

Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health
problems. The evidence for familial aggregation of both T2D and obesity is substantial. To …