Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives
Schistosomes, like many eukaryotic pathogens, typically display morphologically distinct
stages during their life cycles. Epigenetic mechanisms underlie the pathogens' …
stages during their life cycles. Epigenetic mechanisms underlie the pathogens' …
[HTML][HTML] Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study
Exercise training and bariatric surgery have been shown to independently modulate DNA
methylation profile in clusters of genes related to metabolic and inflammatory pathways. This …
methylation profile in clusters of genes related to metabolic and inflammatory pathways. This …
Phylogenomics of the epigenetic toolkit reveals punctate retention of genes across eukaryotes
AKM Weiner, MA Cerón-Romero… - Genome Biology and …, 2020 - academic.oup.com
Epigenetic processes in eukaryotes play important roles through regulation of gene
expression, chromatin structure, and genome rearrangements. The roles of chromatin …
expression, chromatin structure, and genome rearrangements. The roles of chromatin …
Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
J Hu, Y Wang, Y Li, D Cao, L Xu, SS Song… - European Journal of …, 2018 - Elsevier
Recently, several kinase inhibitors were found to also inhibit bromodomains, providing a
new strategy for the discovery of bromodomain inhibitors. Along this line, starting from PLK1 …
new strategy for the discovery of bromodomain inhibitors. Along this line, starting from PLK1 …
Comorbidity, multimorbidity and personalized psychosomatic medicine: epigenetics rolling on the horizon
M Jakovljević, Ž Reiner, D Miličić, Ž Crnčević - Psychiatria Danubina, 2010 - hrcak.srce.hr
Sažetak This rewiew focused first on conceptual chaos and different connotations in
psychosomatic medicine, then on new perspectives on comorbidity and multimorbidity …
psychosomatic medicine, then on new perspectives on comorbidity and multimorbidity …
[HTML][HTML] Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma
HK Wong - Discovery medicine, 2013 - discoverymedicine.com
Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that
develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary …
develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary …
Epigenetics of aging
D Ben-Avraham - Longevity Genes: A Blueprint for Aging, 2015 - Springer
The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors, and it is among the most complex phenotypes studied to date …
environmental factors, and it is among the most complex phenotypes studied to date …
Next-generation sequencing in understanding complex neurological disease
AE Handel, G Disanto… - Expert review of …, 2013 - Taylor & Francis
Next-generation sequencing techniques have made vast quantities of data on human
genomes and transcriptomes available to researchers. Huge progress has been made …
genomes and transcriptomes available to researchers. Huge progress has been made …
Changes in the levels of DNA methylation in testis and liver of SD rats neonatally exposed to 5‐aza‐2′‐deoxycytidine and cadmium
H Zhu, K Li, J Liang, J Zhang… - Journal of Applied …, 2011 - Wiley Online Library
To investigate the changes in the levels of DNA methylation in the testis during development
after neonatal transient exposure to DNA methyltransferase (DNMT) inhibitors, we orally …
after neonatal transient exposure to DNA methyltransferase (DNMT) inhibitors, we orally …
Epigenetics: time to translate into transplantation
JA McCaughan, AJ McKnight, AE Courtney… - …, 2012 - journals.lww.com
Substantial progress has been made in identifying genetic loci associated with multifactorial
disorders, including variants that seem to impact outcomes following solid organ …
disorders, including variants that seem to impact outcomes following solid organ …