Advances and applications of environmental stress adaptation research

LJ Hawkins, KB Storey - Comparative Biochemistry and Physiology Part A …, 2020 - Elsevier
Evolution has produced animals that survive extreme fluctuations in environmental
conditions including freezing temperatures, anoxia, desiccating conditions, and prolonged …

[HTML][HTML] DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia

T Płatek, A Polus, J Góralska, U Raźny, A Gruca… - Molecular …, 2020 - Springer
Background Epigenetics can contribute to lipid disorders in obesity. The DNA methylation
pattern can be the cause or consequence of high blood lipids. The aim of the study was to …

The epigenomics of polycystic ovarian syndrome: from pathogenesis to clinical manifestations

S Li, D Zhu, H Duan, Q Tan - Gynecological Endocrinology, 2016 - Taylor & Francis
Polycystic ovarian syndrome (PCOS) is a complex condition of ovarian dysfunction and
metabolic abnormalities with widely varying clinical manifestations resulting from …

Enhanced histone acetylation in the infralimbic prefrontal cortex is associated with fear extinction

SA Siddiqui, S Singh, V Ranjan, R Ugale… - Cellular and Molecular …, 2017 - Springer
The molecular processes that establish fear memory are complex and involve a combination
of genetic and epigenetic influences. Dysregulation of these processes can manifest in …

[HTML][HTML] Epigenetic therapy for breast cancer

FF Cai, C Kohler, B Zhang, MH Wang, WJ Chen… - International journal of …, 2011 - mdpi.com
Both genetic and epigenetic alterations can control the progression of cancer. Genetic
alterations are impossible to reverse, while epigenetic alterations are reversible. This …

Epigenomics and the microbiota

T Alenghat - Toxicologic pathology, 2015 - journals.sagepub.com
The mammalian gastrointestinal tract is home to trillions of commensal microorganisms that
collectively make up the intestinal microbiota. These microbes are important environmental …

Using epigenome-wide association scans of DNA methylation in age-related complex human traits

PC Tsai, TD Spector, JT Bell - Epigenomics, 2012 - Taylor & Francis
With rapid technological advancements emerging epigenetic studies of complex traits have
shifted from candidate gene analyses towards epigenome-wide association studies (EWAS) …

MS‐275, a Class I histone deacetylase inhibitor, protects the p53‐deficient mouse against ischemic injury

SP Murphy, RJ Lee, ME McClean… - Journal of …, 2014 - Wiley Online Library
The administration of pan histone deacetylase (HDAC) inhibitors reduces ischemic damage
to the CNS, both in vitro and in animal models of stroke, via mechanisms which we are …

Epigenetics in multiple sclerosis

VSF Chan - Epigenetics in allergy and autoimmunity, 2020 - Springer
Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients
slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal …

Association of global DNA hypomethylation with post‐operative cognitive dysfunction in elderly patients undergoing hip surgery

H Li, TT Wu, L Tang, Q Liu, X Mao… - Acta …, 2020 - Wiley Online Library
Background Post‐operative cognitive dysfunction (POCD) is a decline of cognitive status
that commonly occurs after surgery in elderly patients. Whether DNA methylation is …