MHC molecules as peptide receptors

HG Rammensee, K Falk, O Rötzschke - Current opinion in immunology, 1993 - Elsevier
The central unit for regulation of the specific immune system is a trimolecular complex made
up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third …

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

JH Brown, TS Jardetzky, JC Gorga, LJ Stern, RG Urban… - Nature, 1993 - nature.com
The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from
human B-cell membranes has been determined by X-ray crystallography and is similar to …

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

K Falk, O Rötzschke, S Stevanovíc, G Jung… - Immunogenetics, 1994 - Springer
We have approached the problem of MHC class II ligand motifs by pool sequencing natural
peptides eluted from HLA-DR, DQ, and DP molecules. The results indicate surprisingly clear …

[图书][B] Human blood groups: chemical and biochemical basis of antigen specificity

H Schenkel-Brunner - 2000 - books.google.com
As President and organiser of the 26th Congress of the International Society pf Blood
Transfusion'ISBT 2000', I am pleased to introduce this work on the biochemistry of human …

How DNA viruses perturb functional MHC expression to alter immune recognition

G McFadden, K Kane - Advances in cancer research, 1994 - Elsevier
Publisher Summary This chapter focuses on how gene products encoded by DNA viruses
alter MHC expression and function so as to perturb antigen recognition, and thus potentially …

Exon-intron organization of fish major histocompatibility complex class II B genes

H Ono, C O'hUigin, V Vincek, J Klein - Immunogenetics, 1993 - Springer
Major histocompatibility complex (Mhc) molecules bind self and foreign peptides and
present them to lymphocyte for recognition. Activation of lympocytes by Mhc-bound foreign …

Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients

WJ Storkus, MT Lotze - US Patent 6,077,519, 2000 - Google Patents
Methods are provided for eluting peptides that are bound to major histocompatibility
complex (“MHC) molecules expressed on the cell Surfaces of viable cells that have at least …

[HTML][HTML] Peptides bound to major histocompatibility complex molecules

A Maffei, PE Harris - Peptides, 1998 - Elsevier
Maffei, A. and PE Harris. Peptides bound to major histocompatibility complex molecules.
Peptides 19 (1) 179–198, 1998.—Peptides are the means by which immune effector T cells …

Purification and characterization of endogenous peptides extracted from HLA‐DR isolated from the spleen of a patient with rheumatoid arthritis

RD Gordon, JA Young, S Rayner… - European journal of …, 1995 - Wiley Online Library
We have purified HLA‐DR from the spleen of a patient with rheumatoid arthritis. The patient
had Felty's syndrome and was heterozygous for the DR4Dw4 antigen. We have isolated …

Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

E Radley, RP Alderton, A Kelly, J Trowsdale… - Journal of Biological …, 1994 - ASBMB
The genomic nucleotide sequences of HLA-DMA and HLA-DMB have been determined and
their gene organizations have been compared with other human class II genes. The …